Amphiphilic dipyrrinones: methoxylated [6]-semirubins

Amphiphilic Polymethacrylate Derivatives Amphiphilic Polymethacrylate Derivatives

Cationic amphiphilic polymethacrylate derivatives (PMAs) have shown potential as a novel class of synthetic antimicrobials. A panel of PMAs with varied ratios of hydrophobic and cationic side chains were synthesized and tested for antimicrobial activity and mechanism of action. The PMAs are shown to be active against a panel of pathogenic bacteria, including a drug-resistant Staphylococcus aure...

Amphiphilic Membranes

Amphiphilic molecules (the word derives from the Greek αμφὶ φιλία, meaning “love on both sides”) are molecules which both love and hate water. They are formed by two parts with very different tastes, which are covalently bound together: one, the hydrophilic head, is polar or even ionized, and tends therefore to be close to the small, polar water molecules; the other, the hydrophobic tail, is us...

Synthesis of the first amphiphilic pillar[6]arene and its enzyme-responsive self-assembly in water.

The first amphiphilic pillar[6]arene was successfully synthesized. It can complex with adenosine triphosphate to form vesicles in water. Moreover, these vesicles are efficiently responsive to phosphatase.

Antifungal Amphiphilic Aminoglycosides.

The attachment of alkyl and other hydrophobic groups to traditional antibacterial kanamycins and neomycins creates amphiphilic aminoglycosides with altered antimicrobial properties. In this review, we summarize the discovery of amphiphilic kanamycins that are antifungal, but not antibacterial, and that inhibit the growth of fungi by perturbation of plasma membrane functions. With low toxicities...

Amphiphilic Cyclobutenes and Cyclobutanes